Study on the Influencing Factors of Hypoglycemic Effect of Folate Targeted Polymersomes Encapsulating Insulin

PurposeTo study the effects of density folic acid (FA) on hypoglycemic ability FA-targeted polymersomes as oral insulin carriers. Also to change effect mixed added with various mass ratio d-α-tocopherol polyethylene glycol 1000 succinate (TPGS).MethodsThe different FA molar contents were prepared. The in vitro release experiments media for studied. Their quantitative cellular uptake Caco-2 cells was examined. vivo activity also studied diabetic rats. optimal content chosen prepare TPGS contents.ResultsAmong insulin-loaded four contents, 10% (insulin-loaded 10%FA-Ps) showed hightest and best response. In addition, FA-Ps/TPGS5:1 exhibited higher better response than other two adding did.ConclusionsFA-Ps/TPGS5:1 could be a promising formulation administration insulin.